Violations of Bjorken scaling in inclusive e+e- annihilation

We discuss the application of renormalization-group techniques to inclusive e+e- annihilation. It is shown by a modest extension of Mueller's techniques that annihilation structure functions have a behavior completely analogous to electroproduction structure functions: Their moments scale for large virtual photon mass, and this scaling is described by "anomalous dimensions" which have a singularity structure and general form very similar to the usual anomalous dimension, though there is no simple relation between the two. We show how information about the structure functions can be deduced from the moments and how, in appropriate limits, deviations from Bjorken scaling can be interpreted in terms of an underlying field theory

Quantifying selection in immune receptor repertoires

The efficient recognition of pathogens by the adaptive immune system relies on the diversity of receptors displayed at the surface of immune cells. T-cell receptor diversity results from an initial random DNA editing process, called VDJ recombination, followed by functional selection of cells according to the interaction of their surface receptors with self and foreign antigenic peptides. To quantify the effect of selection on the highly variable elements of the receptor, we apply a probabilistic maximum likelihood approach to the analysis of high-throughput sequence data from the $\beta$-chain of human T-cell receptors. We quantify selection factors for V and J gene choice, and for the length and amino-acid composition of the variable region. Our approach is necessary to disentangle the effects of selection from biases inherent in the recombination process. Inferred selection factors differ little between donors, or between naive and memory repertoires. The number of sequences shared between donors is well-predicted by the model, indicating a purely stochastic origin of such "public" sequences. We find a significant correlation between biases induced by VDJ recombination and our inferred selection factors, together with a reduction of diversity during selection. Both effects suggest that natural selection acting on the recombination process has anticipated the selection pressures experienced during somatic evolution

Model calculations of electroproduction and inclusive annihilation cross sections

We have studied "deep-inelastic electroproduction" and "inclusive e+e- annihilation" in massless φ4 theory in the ladder approximation. The relevant Bethe-Salpeter-type equations can be completely solved and the physically important asymptotic limits are studied. The behavior of the moments of the structure functions is analyzed, and the "anomalous dimensions" which govern the asymptotic power behavior of the moments in the two cases are found. The anomalous dimensions are quite different in general, but are simply related in the weak-coupling limit

OLGA: fast computation of generation probabilities of B- and T-cell receptor amino acid sequences and motifs

Motivation: High-throughput sequencing of large immune repertoires has enabled the development of methods to predict the probability of generation by V(D)J recombination of T- and B-cell receptors of any specific nucleotide sequence. These generation probabilities are very non-homogeneous, ranging over 20 orders of magnitude in real repertoires. Since the function of a receptor really depends on its protein sequence, it is important to be able to predict this probability of generation at the amino acid level. However, brute-force summation over all the nucleotide sequences with the correct amino acid translation is computationally intractable. The purpose of this paper is to present a solution to this problem. Results: We use dynamic programming to construct an efficient and flexible algorithm, called OLGA (Optimized Likelihood estimate of immunoGlobulin Amino-acid sequences), for calculating the probability of generating a given CDR3 amino acid sequence or motif, with or without V/J restriction, as a result of V(D)J recombination in B or T cells. We apply it to databases of epitope-specific T-cell receptors to evaluate the probability that a typical human subject will possess T cells responsive to specific disease-associated epitopes. The model prediction shows an excellent agreement with published data. We suggest that OLGA may be a useful tool to guide vaccine design. Availability: Source code is available at https://github.com/zsethna/OLG

Towards the large N limit of pure N=1 super Yang Mills

We find the gravity solution corresponding to a large number of NS or D fivebranes wrapped on a two sphere so that we have pure ${\cal N}=1$ super Yang-Mills in the IR. The supergravity solution is smooth, it shows confinement and it breaks the $U(1)_R$ chiral symmetry in the appropriate way. When the gravity approximation is valid the masses of glueballs are comparable to the masses of Kaluza Klein states on the fivebrane, but if we could quantize strings on this background it looks like we should be able to decouple the KK states.Comment: latex, 12 pages. v2: Reference to a forthcoming paper added. v3 references and clarifications adde

General Composite Higgs Models

We construct a general class of pseudo-Goldstone composite Higgs models, within the minimal SO(5)/SO(4) coset structure, that are not necessarily of moose-type. We characterize the main properties these models should have in order to give rise to a Higgs mass around 125 GeV. We assume the existence of relatively light and weakly coupled spin 1 and 1/2 resonances. In absence of a symmetry principle, we introduce the Minimal Higgs Potential (MHP) hypothesis: the Higgs potential is assumed to be one-loop dominated by the SM fields and the above resonances, with a contribution that is made calculable by imposing suitable generalizations of the first and second Weinberg sum rules. We show that a 125 GeV Higgs requires light, often sub-TeV, fermion resonances. Their presence can also be important for the models to successfully pass the electroweak precision tests. Interestingly enough, the latter can also be passed by models with a heavy Higgs around 320 GeV. The composite Higgs models of the moose-type considered in the literature can be seen as particular limits of our class of models.Comment: 51 pages, 12 figures, 5 appendices; v2: Corrected estimates of \delta g_b in appendix B, references fixed, several minor improvements; v3: minor improvements, to appear in JHE

The 4D Composite Higgs

We propose a four dimensional description of Composite Higgs Models which represents a complete framework for the physics of the Higgs as a pseudo-Nambu-Goldstone boson. Our setup captures all the relevant features of 5D models and more in general of composite Higgs models with partial compositeness. We focus on the minimal scenario where we include a single multiplet of resonances of the composite sector, as these will be the only degrees of freedom which might be accessible at the LHC. This turns out to be sufficient to compute the effective potential and derive phenomenological consequences of the theory. Moreover our simplified approach is well adapted to simulate these models at the LHC. We also consider the impact of non-minimal terms in the effective lagrangian which do not descend from a 5D theory and could be of phenomenological relevance, for example contributing to the S-parameter.Comment: 28 pages, 7 figures. v2) minor changes, references added, to appear in JHE